Employing single-molecule optical and AFM imaging and drive-spectroscopy approaches, we find to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our investigate pursuits include things like:
It had been only during the nineties nevertheless, when nanotechnology had Sophisticated to your level the place one molecules could possibly be manipulated, that the main experimental units commenced to appear.
Multicolor imaging with the bacterial nucleoid and cell division proteins with blue, orange, and close to-infrared fluorescent proteins
I can hardly imagine how I, to be a geneticist, would have the ability to discover elementary physics, let alone contend at the highest. How did you go about this?
2015, discovery that condensin is actually a extremely adaptable protein framework; and initial detection of DNA knots using nanopores
Our analysis ranges through the biophysics of DNA to synthetic cells and over and above. You should take a look underneath with the spectrum of our recent assignments.
MATLAB codes for facts processing are available at . Julia codes useful for numerical simulation can be obtained at .
2000, discovery that nanotubes can carry remarkable significant present densities; solved the controversial issue of electronic transportation via DNA molecules by measurements of insulating habits at The one molecule level; and demonstration of an AFM procedure for single-molecule manipulation of nanotubes
You may also help our writer matching program! Should you discover any publications improperly attributed to this writer, remember to sign in and mark matches as right or incorrect.
It was throughout this period that Dekker completed research on magnetic spin methods and on sound in superconductors and semiconductors.
An built-in microfluidic System for quantifying drug permeation across biomimetic vesicle membranes
‘That problems the synthetic cell, as Element of the Dutch BaSyC initiative. Craig Venter looked top rated-down in These times and discovered about five hundred genes that happen to be minimally essential for a working mobile. We wish to appear base-up: how can we move from a couple molecules to a complete biological process?
Visualization of unstained DNA nanostructures with Sophisticated in-emphasis transmission electron microscopy approaches
The biophysicist from Delft – who is The most cited researchers while in the Netherlands For a long time – will take his duty to contribute cees dekker to the rationalization and popularisation of his get the job done with the border of physics and biology incredibly critically and regularly seems during the media; Otherwise to mention his perform, then about the relationship concerning science and his Christian religion.